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pentobarbital will minimize the level or influence of eplerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.pentobarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of CYP3A4 inducers may decrease sufentanil ran